Cholesterol, a fatty substance, is vital for the normal functioning of the body. It is produced in the liver as well as found in some food items. The risk of heart disease increases with high cholesterol levels in the blood. Excessive deposition of cholesterol in the blood vessels, makes it difficult for the blood to flow through the arteries. As a result, the heart may not get as much oxygen-rich blood as it needs, which increases the risk of a heart attack. Decreased blood flow to the brain can cause a stroke.

According to Ayurvedic texts, balancing MedaDhatu (lipid tissue) subsequently helps to maintain a balanced cholesterol level. Agni (digestive fire) is the principle factor behind the balance in the body. A strong Agni is equally important in maintaining balance in the Doshas and Malas. Therefore, balancing digestion, assimilation, and elimination in turn balances fat tissue and cholesterol. When MedaDhatu mixes with Ama (sticky, foul-smelling waste product of improper digestion), it changes the quality of fat tissue and the quality of cholesterol, making it unhealthy. This mixing of Ama with fat tissue is the main cause of imbalanced cholesterol.